Green Synthesis of a Novel Silver Nanoparticle Conjugated with Thelypteris glandulosolanosa (Raqui-Raqui): Preliminary Characterization and Anticancer Activity

In the last decade, green synthesis of nanoparticles has had a prominent role in scientific research for industrial and biomedical applications. this current study, silver nitrate (AgNO3) was reduced stabilized with an aqueous extract Thelypteris glandulosolanosa (Raqui-raqui), forming (AgNPs-RR). UV-vis spectrophotometry, dynamic light scattering (DLS), scanning transmission electron microscopy (STEM) were utilized to analyze structures AgNPs-RR. The results from analysis showed characteristic peak at 420 nm mean hydrodynamic size equal 39.16 nm, while STEM revealed distribution 6.64–51.00 average diameter 31.45 nm. Cellular cytotoxicity assays using MCF-7 (ATCC® HTB-22™, mammary gland breast), A549 CCL-185, lung epithelial carcinoma), L929 CCL-1, subcutaneous connective tissue Mus musculus) demonstrated over 42.70% MCF-7, 59.24% A549, 8.80% cells cell death after 48 h showing that nanoparticle is more selective disrupt neoplastic than non-cancerous may be further developed into effective strategy breast cancer treatment. These demonstrate surfaces are complex, have lower contact angles, excellent scratch wear resistance.